BioInsights - Vector bioprocessing & raw materials - spotlight

CELL AND GENE THERAPY INSIGHTS INSIGHTS

April 2023

Vector bioprocessing & raw materials

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Innovator Insight

Determination of physical viral vector titer in process development & QC for cell & gene therapy

Determination of physical viral vector titer in process development & QC for cell & gene therapy

Daniel Forssträm, John Chappell

Sustainable plasmid DNA strategies, achieving streamlined secure supply to clinic & commercialization

Sustainable plasmid DNA strategies, achieving streamlined secure supply to clinic & commercialization

Andrew Frazer, Amanda Weiss

Commentary

Opportunities to implement continuous processing in production of recombinant adeno-associated viral vectors

Opportunities to implement continuous processing in production of recombinant adeno-associated viral vectors

G Thakur, S Mink, H Bak et al.

Interview

Exploring the evolution of upstream & downstream viral vector processing

Exploring the evolution of upstream & downstream viral vector processing

Francesca Vitelli

Expert Roundtable

Driving the expansion of mRNA into the therapeutic sphere

Driving the expansion of mRNA into the therapeutic sphere

A Becerra, A Kuhn, M Kurtoglu

Viewpoint

Standardizing success: paving the way for streamlined viral vector manufacturing in gene therapy

Standardizing success: paving the way for streamlined viral vector manufacturing in gene therapy

Raquel Martín-Ibáñez

Setting up a one-stop shop: bringing viral vector manufacturing in-house

Setting up a one-stop shop: bringing viral vector manufacturing in-house

Danielle Steele

Transfection optimization for AAV production

Transfection optimization for AAV production

Peter Boyce

Webinars

The fast and the curious – optimized development of high performing AAV vectors

The fast and the curious – optimized development of high performing AAV vectors

Dirk Grimm, David Schaffer

Advancing the purification of VSV-G pseudotyped lentiviral vectors by using affinity chromatography

Advancing the purification of VSV-G pseudotyped lentiviral vectors by using affinity chromatography

Pim Hermans, Frank Detmers

Case studies: Successful scale-up of upstream viral vector processes using adherent and suspension platforms

Case studies: Successful scale-up of upstream viral vector processes using adherent and suspension platforms

Samir Acharya, Denis Kole

Navigating evolving regulatory CMC guidance in the AAV gene therapy field

Navigating evolving regulatory CMC guidance in the AAV gene therapy field

Y Zhi, C Le Bec, M Brewer et al.

Emerging trends and challenges in AAV manufacturing for gene therapies

Emerging trends and challenges in AAV manufacturing for gene therapies

M Fuller, A Eastham, I (John) Eugenis

Scalable production in single-use bioreactors

Scalable production in single-use bioreactors

Jonathan Zmuda PhD, Premkumar Jayaraman PhD

Chromatographic modalities, buffer selection and other considerations for enrichment of AAV product

Chromatographic modalities, buffer selection and other considerations for enrichment of AAV product

Rok Žigon

De-risking lentiviral vector production using a robust, scalable, suspension-based platform

De-risking lentiviral vector production using a robust, scalable, suspension-based platform

Jimmy Xin, Poornima Manavalan

Skip the hassle for AAV and AdV empty/full and titer data with Stunner

Skip the hassle for AAV and AdV empty/full and titer data with Stunner

Nelis Denys

Development of anti-AAV assay for detection of pre-existing AAV immunity

Development of anti-AAV assay for detection of pre-existing AAV immunity

Zhe Liu, John Chappell

Analyzing full and empty AAV capsid ratio in less than 5 minutes

Analyzing full and empty AAV capsid ratio in less than 5 minutes

Åsa Hagner-McWhirter PhD

High-throughput process & analytical platforms to accelerate gene therapy scale-up

High-throughput process & analytical platforms to accelerate gene therapy scale-up

P Starremans PhD, K Warrington PhD, N Jesuraj PhD

Manufacturing and testing a clinical-grade AAV vector: from concept to clinic

Manufacturing and testing a clinical-grade AAV vector: from concept to clinic

Chris Edwards, James Cody

Future-proof your AAV process with a complete producer cell line – just induce and grow

Future-proof your AAV process with a complete producer cell line – just induce and grow

Dovile Gruzdyte